Lymph transport in rat mesenteric lymphatics experiencing edemagenic stress
Identifieur interne : 002914 ( Main/Exploration ); précédent : 002913; suivant : 002915Lymph transport in rat mesenteric lymphatics experiencing edemagenic stress
Auteurs : Elaheh Rahbar [États-Unis] ; Tony Akl [États-Unis] ; Gerard L. Coté [États-Unis] ; James E. Moore [Royaume-Uni] ; David C. Zawieja [États-Unis]Source :
- Microcirculation (New York, N.Y. : 1994) [ 1073-9688 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Lymphe, Lymphocytes, Mésentère, Oedème.
- physiopathologie : Mésentère, Oedème.
- Animaux, Mâle, Rat Sprague-Dawley, Rats, Stress physiologique, Transport biologique actif.
English descriptors
- KwdEn :
- MESH :
- metabolism : Edema, Lymph, Lymphocytes, Mesentery.
- physiopathology : Edema, Mesentery.
- Animals, Biological Transport, Active, Male, Rats, Rats, Sprague-Dawley, Stress, Physiological.
Abstract
To assess lymphatic flow adaptations to edema, we evaluated lymph transport function in rat mesenteric lymphatics under normal and edemagenic conditions
Twelve rats were infused with saline (intravenous infusion, 0.2 ml/min/100g body weight) to induce edema. We intravitally measured mesenteric lymphatic diameter and contraction frequency, as well as immune cell velocity and density before, during and after infusion.
A 10-fold increase in lymph velocity (0.1–1 mm/s) and a 6-fold increase in flow rate (0.1–0.6 μL/min), were observed post-infusion, respectively. There were also increases in contraction frequency and fractional pump flow 1-minute post-infusion. Time-averaged wall shear stress increased 10 fold post-infusion to nearly 1.5 dynes/cm2. Similarly, maximum shear stress rose from 5 dynes/cm2 to 40 dynes/cm2.
Lymphatic vessels adapted to edemagenic stress by increasing lymph transport. Specifically, the increases in lymphatic contraction frequency, lymph velocity, and shear stress were significant. Lymph pumping increased post-infusion, though changes in lymphatic diameter were not statistically significant. These results indicate that edemagenic conditions stimulate lymph transport via increases in lymphatic contraction frequency, lymph velocity and flow. These changes, consequently, resulted in large increases in wall shear stress, which could then activate NO pathways and modulate lymphatic transport function.
Url:
DOI: 10.1111/micc.12112
PubMed: 24397756
PubMed Central: 4174575
Affiliations:
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Coté</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Biomedical Engineering, Texas A&M University, 5045 Emerging Technologies Building, 3120 TAMU, College Station, TX 77843-3120, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Texas A&M University, 5045 Emerging Technologies Building, 3120 TAMU, College Station, TX 77843-3120</wicri:regionArea><wicri:noRegion>TX 77843-3120</wicri:noRegion></affiliation></author><author><name sortKey="Moore, James E" sort="Moore, James E" uniqKey="Moore J" first="James E." last="Moore">James E. Moore</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Bioengineering Imperial College London South Kensington Campus Royal School of Mines Building, Room 4.14 London SW7 2AZ, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Bioengineering Imperial College London South Kensington Campus Royal School of Mines Building, Room 4.14 London SW7 2AZ</wicri:regionArea><wicri:noRegion>Room 4.14 London SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, 702 SW H.K. Dodgen Loop, Temple, TX 76504, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, 702 SW H.K. Dodgen Loop, Temple, TX 76504</wicri:regionArea><wicri:noRegion>TX 76504</wicri:noRegion></affiliation></author></analytic><series><title level="j">Microcirculation (New York, N.Y. : 1994)</title><idno type="ISSN">1073-9688</idno><idno type="eISSN">1549-8719</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Transport, Active</term><term>Edema (metabolism)</term><term>Edema (physiopathology)</term><term>Lymph (metabolism)</term><term>Lymphocytes (metabolism)</term><term>Male</term><term>Mesentery (metabolism)</term><term>Mesentery (physiopathology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Stress, Physiological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Lymphe (métabolisme)</term><term>Lymphocytes (métabolisme)</term><term>Mâle</term><term>Mésentère (métabolisme)</term><term>Mésentère (physiopathologie)</term><term>Oedème (métabolisme)</term><term>Oedème (physiopathologie)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Stress physiologique</term><term>Transport biologique actif</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Edema</term><term>Lymph</term><term>Lymphocytes</term><term>Mesentery</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphe</term><term>Lymphocytes</term><term>Mésentère</term><term>Oedème</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Mésentère</term><term>Oedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Edema</term><term>Mesentery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Transport, Active</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Stress physiologique</term><term>Transport biologique actif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To assess lymphatic flow adaptations to edema, we evaluated lymph transport function in rat mesenteric lymphatics under normal and edemagenic conditions <italic>in situ</italic>.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Twelve rats were infused with saline (intravenous infusion, 0.2 ml/min/100g body weight) to induce edema. We intravitally measured mesenteric lymphatic diameter and contraction frequency, as well as immune cell velocity and density before, during and after infusion.</p></sec><sec id="S3"><title>Results</title><p id="P3">A 10-fold increase in lymph velocity (0.1–1 mm/s) and a 6-fold increase in flow rate (0.1–0.6 μL/min), were observed post-infusion, respectively. There were also increases in contraction frequency and fractional pump flow 1-minute post-infusion. Time-averaged wall shear stress increased 10 fold post-infusion to nearly 1.5 dynes/cm<sup>2</sup>. Similarly, maximum shear stress rose from 5 dynes/cm<sup>2</sup> to 40 dynes/cm<sup>2</sup>.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Lymphatic vessels adapted to edemagenic stress by increasing lymph transport. Specifically, the increases in lymphatic contraction frequency, lymph velocity, and shear stress were significant. Lymph pumping increased post-infusion, though changes in lymphatic diameter were not statistically significant. These results indicate that edemagenic conditions stimulate lymph transport via increases in lymphatic contraction frequency, lymph velocity and flow. These changes, consequently, resulted in large increases in wall shear stress, which could then activate NO pathways and modulate lymphatic transport function.</p></sec></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Rahbar, Elaheh" sort="Rahbar, Elaheh" uniqKey="Rahbar E" first="Elaheh" last="Rahbar">Elaheh Rahbar</name></noRegion><name sortKey="Akl, Tony" sort="Akl, Tony" uniqKey="Akl T" first="Tony" last="Akl">Tony Akl</name><name sortKey="Cote, Gerard L" sort="Cote, Gerard L" uniqKey="Cote G" first="Gerard L." last="Coté">Gerard L. Coté</name><name sortKey="Zawieja, David C" sort="Zawieja, David C" uniqKey="Zawieja D" first="David C." last="Zawieja">David C. Zawieja</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Moore, James E" sort="Moore, James E" uniqKey="Moore J" first="James E." last="Moore">James E. Moore</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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